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Pathology Quiz 3
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Yichieh Shiuey, MD | Massachusetts Eye and Ear Infirmary, Harvard Medical School

August 4, 1997
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Figure 1
Figures 1-2. This is the pathology of the cornea of a patient who underwent penetrating keratoplasty. The stain used is congo red.
Figure 2
Questions and Answers
1. What is the diagnosis?
Answer: lattice corneal stromal dystrophy

2. What are the pathological findings shown?
Answer: Reddish staining of intrastromal deposits.

3. What is the composition of the stromal deposits?
Answer: The deposits are composed of amyloid

4. If the specimen were examined with a polarizing filter, what would be seen?
Answer: Amyloid deposits demonstrate a green birefringence when viewed with a polarizing filter

5. What kinds of systemic manifestations can be seen in this condition?
Answer: Systemic amyloidosis involving the skin arteries and other organs occurs in the Meretoja (Type II) variant of lattice stromal dystrophy. These patients may have facial paralysis and blepharochalasis after age 40.

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