Kristin Torroella | George Washington School of Medicine and Health Sciences, Washington, DCGeorge Washington School of Medicine and Health Sciences, Washington, DC Jana Bregman, MD | Department of Ophthalmology, Childrens National Hospital, Washington, DC Maria Isabel Almira-Suarez, MD, FASCP | Neuropathology Service, Division of Anatomic Pathology, Childrens National Hospital, Washington, DC Marijean Miller, MD | Department of Ophthalmology, Childrens National Hospital, Washington, DC
A 10-year-old girl with a known diagnosis of MEN2B and a history of medullary thyroid cancer (MTC) presented at Children’s National Hospital ophthalmology clinic with recurrent eyelid lesions. She had a history of hypothyroidism, mild hypocalcemia, and café-au-lait spots—all consistent with her MEN2B diagnosis. She was already followed closely by her pediatrician as well as an endocrinologist. There was no prior family history of MEN2B. The patient had undergone repeat shave biopsies of the eyelid lesions at an outside facility on two separate occasions and was experiencing regrowth after just one year. She noted that the lesions had continued to increase in size and was bothered by their appearance as well as by associated ocular surface irritation.